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Meta I've just tried several online search engines. I've also downloaded different versions of the package and also searched for the download key free for seven from several websites. All of them failed to complete successful. The link also don't have a version that work for the current versions. All of them claim they're going to be released soon.Experiments relating to the metabolism of tetrahydrobenz[alpha]anthracene (THBA) will be continued in both rat and mouse skin. Since formaldehyde (one of the products of the reduction of THBA) is a carcinogen, the influence of formaldehyde on the rate of 7,12-dimethylbenz(a)anthracene (DMBA) bioactivation in mouse skin will be investigated. A number of derivatives of THBA, which possess improved water solubility or reduced redox potential, will be examined to see whether they can be used to increase the rate of DMBA bioactivation. Stereoselective reduction of THBA will be determined. Metabolic studies will be extended to include human skin of the head and neck.Intrinsic and extrinsic factors regulating GABAergic gene expression and gamma-aminobutyric acid immunoreactivity in the embryonic brain. It is well established that gamma-aminobutyric acid (GABA) is one of the key inhibitory transmitters in the brain. To establish which extrinsic and intrinsic factors could be regulating the expression of the GABAA receptor and GABA synthetase genes during brain development, the expression and distribution of GABAA receptor (GABAR), GABA synthetic enzyme (GAD) and their protein products were examined in the rat embryonic brain. GABAR alpha, GABAR beta2 and GABAR gamma2, GAD 65 and GAD 67 were detected in the rat brain from embryonic day 14. Tissue distribution and cellular localization studies were performed on embryonic (E14), postnatal (P14, P21, P42) and adult (2-6 months) rats. In situ hybridization and immunocytochemistry experiments were performed on the same tissue sections using 35S-labeled antisense RNA probes. The results revealed a characteristic spatio-temporal expression pattern for GABAR alpha, GABAR gamma2 and GAD 65 protein products. GABAR gamma1 mRNA was not detected in the embryonic and postnatal rat brain, although it was present in the adult brain.